One of my life-defining trips was a backpacking trip to Big Bend. Was probably only the 2nd time I'd gone backpacking and the 1st I'd ever been in the desert Southwest. I feel in love with the desert and the memory of driving into the park, seeing javelina crossing the road, St. Elena Canyon to my left and canyons stretching off to my right in the glow of a March sunset is one I will treasure for the rest of my life. Its been over 14 yrs and I often feel like I'm still on that road. I can honestly say I wouldn't have the passion for the backcountry and the SW if it weren't for my trip to Big Bend.
A buddy of mine and I drove to Big Bend from Chicago. What a drive. Took us about 26 hrs including a quick nap at a rest stop in OK someplace. The logistics are tough, but for me, an Ohioan who never really explored anything remotely like it, the journey GETTING there was fun. Its in the middle of nowhere for sure, but I really enjoyed the drive along the southern part of Texas. Plains of scrub oak, etc. You get the picture.
Anyways, I'm rambling. We initially had planned a 3 day loop around Chisos basin but I ended up getting the flu the 1st day in and we ended up just car camping at a campground and doing small day hikes.
Whatever you do, do not miss the hot springs on the Rio Grande. Ended up going there one night. Great times.